Newsletters
Dear members,
Please find below the latest NVF Newsletter:
Newsletter Dutch Pharmacological Society – December 2022
Newsletter Dutch Pharmacological Society -December 2021
Newsletter Dutch Pharmacological Society -January 2021
Newsletter Dutch Pharmacological Society – July 2020
Newsletter Dutch Pharmacological Society- February 2020
Publications
Placental disposition of eculizumab, C5 and C5-eculizumab in two pregnancies of a woman with paroxysmal nocturnal
Toxicity of anticancer drugs in human placental tissue explants and trophoblast cell lines. Gaby A M Eliesen, Hedwig van Hove, Maartje H Meijer, Petra H H van den Broek, Jeanne Pertijs, Nel Roeleveld, Joris van Drongelen, Frans G M Russel, Rick Greupink, Arch Toxicol. 2021 Feb;95(2):557-571. doi: 10.1007/s00204-020-02925-w.
Physiologically based pharmacokinetic/
Stimulation of cholesterol biosynthesis in mitochondrial complex I-deficiency lowers reductive stress and improves motor function and survival in mice. Schirris TJJ, Rossell S, de Haas R, Frambach SJCM, Hoogstraten CA, Renkema GH, Beyrath JD, Willems PHGM, Huynen MA, Smeitink JAM, Russel FGM, Notebaart RA. Biochim Biophys Acta Mol Basis Dis. 2021 Apr 1;1867(4):166062. doi:10.1016/j.bbadis.2020.166062. Epub 2021 Jan 13.
Imaging Techniques in Alzheimer’s Disease: A Review of Applications in Early Diagnosis and Longitudinal Monitoring. WM van Oostveen, ECM de Lange. Imaging Techniques in Alzheimer’s Disease: A Review of Applications in Early Diagnosis and Longitudinal Monitoring. Review Int J Mol Sci. 2021 doi:10.3390/ijms22042110.
Impact of CNS Diseases on Drug Delivery to Brain Extracellular and Intracellular Target Sites in Human: A “WHAT-IF” Simulation Study. Saleh MAA, De Lange ECM. Pharmaceutics 2021. Doi:10.3390/
The 3D Brain Unit Network Model to Study Spatial Brain Drug Exposure under Healthy and Pathological Conditions. E Vendel, V Rottschäfer, ECM de Lange. Pharm Res. 2020. doi: 10.1007/s11095-020-2760-y.
Utility of Animal Models to Understand Human Alzheimer’s Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals. Qin T, Prins S, Groeneveld GJ, Van Westen G, de Vries HE, Wong YC, Bischoff LJM, de Lange ECM. Int J Mol Sci. 2020. doi: 10.3390/ijms21093158.
Effects of daily L-dopa administration on learning and brain structure in older adults undergoing cognitive training: a randomised clinical trial. A Lebedev, J Nilsson, J Lindström, W Fredborg, U Akenine, C Hillilä, P Andersen, G Spulber, ECM de Lange, DJ van den Berg, M Kivipelto, M Lövden. Sci Rep. 2020. DOI: 10.1038/s41598-020-62172-y
Mitochondrial dysfunction in neurodegenerative diseases: A focus on iPSC-derived neuronal models. Cell Calcium. 2021 Mar;94:102362. doi: 10.1016/j.ceca.2021.102362. Epub 2021 Jan 30.
Microglia alterations in neurodegenerative diseases and their modeling with human induced pluripotent stem cell and other platforms. Prog Neurobiol. 2020 Jul;190:101805. doi: 10.1016/j.pneurobio.2020.101805. Epub 2020 Apr 24.PMID: 32335273
Advanced Modeling of Peripheral Neuro-Effector Communication and -Plasticity. Physiology (Bethesda). 2020 Sep 1;35(5):348-357. doi:10.1152/physiol.00010.2020.PMID: 32783607
Covid-19- related research
Please find below the latest peer-reviewed articles published by members of our Society on Covid-19-related effects:
Rapid Implementation of Model-Based Dosing Recommendations During the Coronavirus Disease 2019 Pandemic. de Wildt SN, Verscheijden LFM, van der Zanden TM. JAMA Pediatr. 2021 Jan 4. doi: 10.1001/jamapediatrics.2020.
Effects of Renin-Angiotensin Inhibition on ACE2 (Angiotensin-Converting Enzyme 2) and TMPRSS2 (Transmembrane Protease Serine 2) Expression: Insights Into COVID-19. Congqing Wu, Dien Ye , Adam E. Mullick, Zhenyu Li, A.H. Jan Danser, Alan Daugherty, Hong S. Lu, Hypertension. 2020 Oct;76(4):e29-e30.
Reduced vitamin K status as a potentially modifiable risk factor of severe COVID-19 Anton S.M. Dofferhoff, Ianthe Piscaer, Leon J. Schurgers, Margot P.J. Visser, Jody M.W. van den Ouweland, Pim A. de Jong, Reinoud Gosens, Tilman M. Hackeng, Henny van Daal, Petra Lux, Cecile Maassen, Esther G.A. Karssemeijer, Cees Vermeer, Emiel F.M. Wouter, Loes E.M. Kistemaker, Jona Walk, Rob Janssen, Clin Infect Dis. 2020 Aug 27 : ciaa1258.
Headache medication and the COVID-19 pandemic. Maassen Van Den Brink A, de Vries T, Danser AHJ.Version 2. J Headache Pain. 2020 Apr 25;21(1):38. doi: 10.1186/s10194-020-01106-5.
Chloroquine Dosing Recommendations for Pediatric COVID‐19 Supported by Modeling and Simulation. Verscheijden LFM, van der Zanden TM, van Bussel LPM, de Hoop-Sommen M, Russel FGM, Johnson TN, de Wildt SN., Clin Pharmacol Ther. 2020 Aug;108(2):248-252. doi: https://doi.org/10.1002/cpt.1864
Effects of Renin-Angiotensin Inhibition on ACE2 and TMPRSS2 Expression: Insights into COVID-19. Wu C, Ye D, Mullick AE, Li Z, Danser AHJ, Daugherty A, Lu HS.Version 3. bioRxiv. 2020 Jun 18:2020.06.08.137331. doi: 10.1101/2020.06.08.137331.
Impaired Breakdown of Bradykinin and Its Metabolites as a Possible Cause for Pulmonary Edema in COVID-19 Infection, de Maat S, de Mast Q, Danser AHJ, van de Veerdonk FL, Maas C. Semin Thromb Hemost. 2020 Jun 11. doi: 10.1055/s-0040-1712960.
Angiotensin-converting enzyme-2 in SARS-CoV-2 infection: good or bad? Versmissen J, Verdonk K, Lafeber M, van den Akker JPC, Hunfeld NGM, Hoorn EJ, Danser AHJ. J Hypertens. 2020 Jun;38(6):1196-1197. doi: 10.1097/HJH.0000000000002472.
[Medication and comedication in COVID-19 patients] [Article in Dutch] M Lenkens, H de Wit, AH Danser, AC Esselink, A Horikx, J Ten Oever, F van de Veerdonk, C Kramers, Ned Tijdschr Geneeskd. 2020 Mar 25;164:D4995.
Renin-Angiotensin System Blockers and the COVID-19 Pandemic: At Present There Is No Evidence to Abandon Renin-Angiotensin System Blockers. Danser AHJ, Epstein M, Batlle D.Version 2. Hypertension. 2020 Jun;75(6):1382-1385. doi: 10.1161/HYPERTENSIONAHA.120.15082.
I am text block. Click edit button to change this text. Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut elit tellus, luctus nec ullamcorper mattis, pulvinar dapibus leo.