Newsletters & Publications & News on Covid-19-related research

Home News Newsletters & Publications & News on Covid-19-related research


Dear members,

Please find below the latest NVF Newsletter:

Newsletter Dutch Pharmacological Society – December 2022

Newsletter Dutch Pharmacological Society -December 2021

Newsletter Dutch Pharmacological Society -January 2021

Newsletter Dutch Pharmacological Society – July 2020

Newsletter Dutch Pharmacological Society- February 2020


Placental disposition of eculizumab, C5 and C5-eculizumab in two pregnancies of a woman with paroxysmal nocturnal haemoglobinuria. Gaby A M Eliesen, Joris van Drongelen, Petra H H van den Broek, Andrei Sarlea, Olivier W H van der Heijden, Saskia Langemeijer, Rick Greupink, Elena B Volokhina, Frans G M Russel, Br J Clin Pharmacol. 2021 Apr;87(4):2128-2131. doi:10.1111/bcp.14565. Epub 2020 Nov 2.

Toxicity of anticancer drugs in human placental tissue explants and trophoblast cell lines. Gaby A M Eliesen, Hedwig van Hove, Maartje H Meijer, Petra H H van den Broek, Jeanne Pertijs, Nel Roeleveld, Joris van Drongelen, Frans G M Russel, Rick Greupink, Arch Toxicol. 2021 Feb;95(2):557-571. doi: 10.1007/s00204-020-02925-w. Epub 2020 Oct 20.

Physiologically based pharmacokinetic/pharmacodynamic model for the prediction of morphine brain disposition and analgesia in adults and children. Verscheijden LFM, Litjens CHC, Koenderink JB, Mathijssen RHJ, Verbeek MM, de Wildt SN, Russel FGM. PLoS Comput Biol. 2021 Mar 4;17(3):e1008786. doi: 10.1371/journal.pcbi.1008786. eCollection 2021 Mar. PMID: 33661919

Stimulation of cholesterol biosynthesis in mitochondrial complex I-deficiency lowers reductive stress and improves motor function and survival in mice. Schirris TJJ, Rossell S, de Haas R, Frambach SJCM, Hoogstraten CA, Renkema GH, Beyrath JD, Willems PHGM, Huynen MA, Smeitink JAM, Russel FGM, Notebaart RA. Biochim Biophys Acta Mol Basis Dis. 2021 Apr 1;1867(4):166062. doi:10.1016/j.bbadis.2020.166062. Epub 2021 Jan 13.

Imaging Techniques in Alzheimer’s Disease: A Review of Applications in Early Diagnosis and Longitudinal Monitoring. WM van Oostveen, ECM de Lange. Imaging Techniques in Alzheimer’s Disease: A Review of Applications in Early Diagnosis and Longitudinal Monitoring. Review Int J Mol Sci.  2021 doi:10.3390/ijms22042110.

Impact of CNS Diseases on Drug Delivery to Brain Extracellular and Intracellular Target Sites in Human: A “WHAT-IF” Simulation Study. Saleh MAA, De Lange ECM. Pharmaceutics 2021. Doi:10.3390/pharmaceutics13010095

The 3D Brain Unit Network Model to Study Spatial Brain Drug Exposure under Healthy and Pathological Conditions. E Vendel, V Rottschäfer, ECM de Lange. Pharm Res. 2020. doi: 10.1007/s11095-020-2760-y.

Utility of Animal Models to Understand Human Alzheimer’s Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals. Qin T, Prins S, Groeneveld GJ, Van Westen G, de Vries HE, Wong YC, Bischoff LJM, de Lange ECM. Int J Mol Sci. 2020. doi: 10.3390/ijms21093158.

Effects of daily L-dopa administration on learning and brain structure in older adults undergoing cognitive training: a randomised clinical trial. A Lebedev, J Nilsson, J Lindström, W Fredborg, U Akenine, C Hillilä, P Andersen, G Spulber, ECM de Lange, DJ van den Berg, M Kivipelto, M Lövden. Sci Rep. 2020. DOI: 10.1038/s41598-020-62172-y

Mitochondrial dysfunction in neurodegenerative diseases: A focus on iPSC-derived neuronal models. Trombetta-Lima M, Sabogal-Guáqueta AM, Dolga AM.Cell Calcium. 2021 Mar;94:102362. doi: 10.1016/j.ceca.2021.102362. Epub 2021 Jan 30.

Microglia alterations in neurodegenerative diseases and their modeling with human induced pluripotent stem cell and other platforms. Sabogal-Guáqueta AM, Marmolejo-Garza A, de Pádua VP, Eggen B, Boddeke E, Dolga AM.Prog Neurobiol. 2020 Jul;190:101805. doi: 10.1016/j.pneurobio.2020.101805. Epub 2020 Apr 24.PMID: 32335273

Advanced Modeling of Peripheral Neuro-Effector Communication and -Plasticity. Goldsteen PA, Dolga AM, Gosens R. Physiology (Bethesda). 2020 Sep 1;35(5):348-357. doi:10.1152/physiol.00010.2020.PMID: 32783607


Covid-19- related research

Please find below the latest peer-reviewed articles published by members of our Society on Covid-19-related effects:

Rapid Implementation of Model-Based Dosing Recommendations During the Coronavirus Disease 2019 Pandemic. de Wildt SN, Verscheijden LFM, van der Zanden TM. JAMA Pediatr. 2021 Jan 4. doi: 10.1001/jamapediatrics.2020.5395. Online ahead of print. PMID: 33393986

Effects of Renin-Angiotensin Inhibition on ACE2 (Angiotensin-Converting Enzyme 2) and TMPRSS2 (Transmembrane Protease Serine 2) Expression: Insights Into COVID-19. Congqing Wu, Dien Ye , Adam E. Mullick, Zhenyu Li, A.H. Jan Danser, Alan Daugherty, Hong S. Lu, Hypertension. 2020 Oct;76(4):e29-e30.

Reduced vitamin K status as a potentially modifiable risk factor of severe COVID-19 Anton S.M. Dofferhoff, Ianthe Piscaer, Leon J. Schurgers, Margot P.J. Visser, Jody M.W. van den Ouweland, Pim A. de Jong, Reinoud Gosens, Tilman M. Hackeng, Henny van Daal, Petra Lux, Cecile Maassen, Esther G.A. Karssemeijer, Cees Vermeer, Emiel F.M. Wouter, Loes E.M. Kistemaker, Jona Walk, Rob Janssen, . 2020 Aug 27 : ciaa1258.

Headache medication and the COVID-19 pandemic. Maassen Van Den Brink A, de Vries T, Danser AHJ.Version 2. J Headache Pain. 2020 Apr 25;21(1):38. doi: 10.1186/s10194-020-01106-5.

Chloroquine Dosing Recommendations for Pediatric COVID‐19 Supported by Modeling and Simulation. Verscheijden LFM, van der Zanden TM, van Bussel LPM, de Hoop-Sommen M, Russel FGM, Johnson TN, de Wildt SN., Clin Pharmacol Ther. 2020 Aug;108(2):248-252. doi:

Effects of Renin-Angiotensin Inhibition on ACE2 and TMPRSS2 Expression: Insights into COVID-19. Wu C, Ye D, Mullick AE, Li Z, Danser AHJ, Daugherty A, Lu HS.Version 3. bioRxiv. 2020 Jun 18:2020.06.08.137331. doi: 10.1101/2020.06.08.137331.

Impaired Breakdown of Bradykinin and Its Metabolites as a Possible Cause for Pulmonary Edema in COVID-19 Infection, de Maat S, de Mast Q, Danser AHJ, van de Veerdonk FL, Maas C. Semin Thromb Hemost. 2020 Jun 11. doi: 10.1055/s-0040-1712960.

Angiotensin-converting enzyme-2 in SARS-CoV-2 infection: good or bad? Versmissen J, Verdonk K, Lafeber M, van den Akker JPC, Hunfeld NGM, Hoorn EJ, Danser AHJ. J Hypertens. 2020 Jun;38(6):1196-1197. doi: 10.1097/HJH.0000000000002472.

[Medication and comedication in COVID-19 patients] [Article in Dutch] M Lenkens, H de Wit, AH Danser, AC Esselink, A Horikx, J Ten Oever, F van de Veerdonk, C Kramers, Ned Tijdschr Geneeskd. 2020 Mar 25;164:D4995.

Renin-Angiotensin System Blockers and the COVID-19 Pandemic: At Present There Is No Evidence to Abandon Renin-Angiotensin System Blockers. Danser AHJ, Epstein M, Batlle D.Version 2. Hypertension. 2020 Jun;75(6):1382-1385. doi: 10.1161/HYPERTENSIONAHA.120.15082.

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