Our new NVF Seminar series will start on the 7th of July, 17-18:00 o’clock and will have Prof. Reinoud Gosens as first speaker.
7th of July, 17-18:00 o’clock
The details for the zoom link are below:
Join Zoom Meeting
Meeting ID: 882 3793 0295
1. Prof Reinoud Gosens, Department of Molecular Pharmacology, University of Groningen
Title: Pharmacological targeting of tissue remodeling and repair in the respiratory tract.
My current research interests are focused on mechanisms that regulate structural remodelling and repair of the airways and lung parenchyma in asthma and COPD. Identifying novel therapeutics for chronic lung disease is my long-term scientific goal. In this endeavour, I focus my work on the one hand on asthmatic airway remodeling, and in particular on the regulation of this pathological process by cholinergic receptors and the airway cholinergic system. Using in vivo and in vitro models the aim is to unravel the muscarinic receptor subtypes and signaling involved. Moreover, we are interested in the mechanisms that regulate plasticity of the airway neural network in asthma for which we recently established stem cell-derived airway cholinergic neurons. A second focus of my work is regenerative pharmacology of the distal lung in COPD and IPF. Here, my research interests are mainly centered around the function and dysfunction of distal lung stem cells/progenitors in health and disease. In particular, I am interested in understanding progenitor cell-niche interactions in disease as a potential background for the discovery of novel drug targets. In my presentation, I will shortly discuss both research lines and invite collaboration in each of these areas.
Wednesday 15th of September, 17-18:00 o’clock
2. Prof. Anton Roks, Department Internal Medicine, Erasmus MC
Title: Modeling of vascular aging and drug target identification with DNA repair mutant mice.
Aging is the single largest cause of disease in economically advanced societies. Cardiovascular disease is strongly represented in this context. Non-atherosclerotic vascular aging is a growing topic, its implications in health and life span being increasingly appreciated. This used to be a problematic filed of research due to the lack of convenient methods. In recent years I have developed mouse models to explore this type of vascular aging, namely by partial inactivation of DNA repair in vascular cells. Persistent activation of DNA damage response leads to accelerated development of aging features independently from the presence of risk factors. In my presentation I will illustrate how this impacts cardiovascular function in comparison to the typical risk factor-induced problems. Also, I will show how my lab has identified relevant drug targets using accelerated vascular aging mice. Very recently I have developed an interest in redox regulation, and I am trying to develop this as a research line, again placing drug development center stage. My lab does not have all the required experience and facilities to examine important aspects of redox regulation, and I kindly invite anyone skilled for collaboration. Furthermore, we are collecting tissues continuously and I would be happy to share tissues with anyone who is interested.
ONLINE EUROoCS 2021 conference:
Thursday – Friday 1-2 July 2021
Deadline for abstract submission is 15 April 2021
Quantitative Systems Pharmacology Conference
Due to the current corona virus situation, this meeting has been postponed to 7-9 April 2021, at Stadsgehoorzaal, Leiden
We are proud to announce that the program for the Quantitative Systems Pharmacology Conference 2021 (QSPC2021) is now available on our website: https://www.qspc.eu/qspc2020/wiki/452397/program.
QSPC2020 will be held in the historic city center of Leiden, the Netherlands on April 7-9, 2021. The focus of QSPC2020 will be on emerging computational and experimental approaches in the field of quantitative systems pharmacology and mechanism-based or physiologically-based PK and PK/PD. The meeting will include plenary lectures by both established and young scientists, poster presentations, and ample opportunities for networking.
For registration please visit: https://www.qspc.eu/qspc2020/subscribe. Note: the number of participants is limited to 500, and registrations will be on a first-come, first-served basis.
Also, we now invite the submission of scientific abstracts for poster presentations, of which some will be selected for flash presentations as part of the plenary sessions.
– Early bird registration closes December 31, 2019
– Abstract submission deadline is January 31, 2020.
We look forward to welcome you in Leiden!
Liesbeth de Lange, Coen van Hasselt, and Elke Krekels,
Organizing committee QSPC2020
NVBMB Spring Symposium
The Netherlands Society for Biochemistry and Molecular Biology (NVBMB) Spring Symposium ‘Mitochondrial physiology and pathology‘ in Nijmegen has been postponed till the spring of 2021. The Westenbrink prizes of 2018/2019 and 2019/2020 will be handed out during this meeting.
More information can be found here.